The Immunodeficiency of CLL

Dr. Terry Hamblin was a retired Professor of Immunohaematology and Editor in Chief of the journal Leukemia Research who passed away in 2012. It is a very informative–and at times religious-political–blog, mutations of mortality, from which one can develop a substantial understanding of immune deficiencies.

Following is a selection of quotes abstracted from his May 8, 2008 post. For the full text, Read more….

  • Patients with chronic lymphocytic leukaemia (CLL) are all to a degree immunodeficient. The most obvious and well-known abnormality is hypogammaglobulinaemia which is present in up to 85% of patients [1].
  • Infections are the major cause of death in between a quarter and a half of patients with CLL [1].
  • The extent of hypogammaglobulinaemia depends on the stage and duration of the disease. Older papers described serum IgA as the first immunoglobulin to be reduced followed by IgM and IgG [2], but this is by no means invariable and most patients have depression of all classes of immunoglobulin.
  • Despite the low levels of serum immunoglobulins, most patients suffer no clinical consequences from this, and in one study 65% of bacterial infections occurred with serum IgG levels below 300 mg/dL [4]. It is recommended that patients with primary immunodeficiency begin immunoglobulin replacement therapy when the serum IgG falls below this level.
  • Apart from bacterial infections, patients with CLL also suffer from the reactivation of herpes viruses. Most commonly this involves herpes zoster.
  • Recurrent attacks of herpes simplex also occur in some untreated patients.

In subsequent posts, Dr. Hamblin discussed the topic in much greater, clinical depth. Read More…

A blogger, Chemo Brain, makes the following recommendations regarding Dr. Hamblin’s website:

If you are new to CLL, then read the following three posts, “What is the aim of treatment” Part 1 – Part 2 – Part 3. At the same time read “Who Needs Treatment?” – this will give you a balanced start in the process of learning about CLL. I think you should also read “Alternative Medicine” too, also as part of a sensible introduction to the illness.


4 Responses to The Immunodeficiency of CLL

  1. Have Hope says:

    Dr Hambin passed away 2012. I would like for you to update your blog. He does not “maintain” (as you wrote) his blog anymore. Please respect the great doctor…update your site/blog. Thank you!

  2. News Article says:

    Howdy! I know this is kinda off topic but I’d figured I’d ask. Would you be interested in trading links or maybe guest writing a blog article or vice-versa? My website discusses a lot of the same topics as yours and I feel we could greatly benefit from each other. If you’re interested feel free to shoot me an e-mail. I look forward to hearing from you! Terrific blog by the wayA

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