Immunoglobulin Basics

  • Immunoglobulins, also known as antibodies, are substances made by the body’s immune system in response to bacteria, viruses, fungus, animal dander, or cancer cells.
  • There are five major types of  immuglobulin (Ig):

Normal Immunoglobulins Levels for Adults

IgA       85-385 milligrams per deciliter (mg/dL)

IgG       565-1765 mg/dL

IgM      55-375 mg/dL

People with very low immunoglobulin levels, especially IgA, IgG, and IgM, have a higher chance of developing an infection. – WebMD

More about Ig Levels – Normal, Above, and Below

Each antibody binds to a specific antigen; an interaction similar to a lock and key. – source: Wikipedia

B-cells Control the Formation of Immunoglobulins

 Immunoglobulin molecules are “Y” shaped structures, anchored at the stem, with the tips of the “Y” acting as the business end. The job of the genes controlling its formation is to see that the tips (Variable Region) immunoglobulin molecule have exactly right shaped pincers for matching the antigen. This is what is meant by the term “IgVH mutation”, mutation of the gene controlling the shape of the Variable region of the Heavy chain of the Immunoglobulin. Read more…  


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